AIMEDIC Publications

Analysis of factors affecting Ca2+‐dependent inactivation dynamics of L‐type Ca2+ current of cardiac myocytes in pulmonary vein of rabbit

Category

Pub

Date

2012-09-01

Source

The Journal of Physiology

•  L‐type Ca2+ channels are inactivated by an increase in intracellular [Ca2+], known as Ca2+‐dependent inactivation (CDI), and are inhibited by Ca2+ released from the sarcoplasmic reticulum (SR), known as release‐dependent inhibition (RDI). •  RDI was greatly enhanced by the removal of Na+–Ca2+ exchange (Incx), and attenuated by blocking Ca2+ release from the sarcoplasmic reticulum (SR), and abolished by Ca2+ chelator. •  We analysed the role of ICaL, SR and Incx and found Incx prevented CDI by controlling [Ca2+] in the junctional subsarcolemmal space ([Ca2+]JSS). •  With previously developed model and the addition of Ca2+ binding kinetics of L‐type Ca2+ channels (ICaLs), we successfully reproduced CDI and RDI. •  From this simulation, we found Incx actively participated in controlling CDI by the regulation of [Ca2+]JSS and by controlling SR Ca2+ refilling.

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