AIMEDIC Publications

Mathematical analysis of the long-term efficacy of daily home hemodialysis therapy with a cold dialysate regeneration system

Category

Pub

Date

2010-10-08

Source

Blood purification

Background/Aim: We previously developed the cold dialysate regeneration system (CDRS) for use in daily home hemodialysis (HD). This study evaluates the long-term efficacy of the CDRS using a mathematical method. Method: HD with the CDRS was simulated using a method that integrates the mass-transfer model and the dialyzer solute kinetics model with a newly proposed model of CDRS function. Results: We mathematically assessed the long-term efficacy of HD with the CDRS. The weekly treatment time required for HD with the CDRS was reduced significantly using the daily dialysis method; it required only an 11% longer treatment time to obtain the corrected equivalent renal clearance and a 14% shorter time for the standard Kt/V, compared with thrice weekly treatment with conventional HD. Conclusion: By developing a mathematical model to test the long-term efficacy of the new CDRS, we …

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