AIMEDIC Publications

Magnetocardiographic pattern analysis of re-entry wave propagation in three-dimensional ventricular tissue by using a human cardiac cell model

Category

Pub

Date

2007-01-15

Source

Journal of the Korean Physical Society

We present a computational study of re-entry wave propagation which were does using an electrophysiological model of a human ventricular cell and the associated magnetic field map in three-dimensional (3D) cardiac tissue. A re-entry wave caused by cardiac disease can induce ventricular fibrillation, the major cause of sudden cardiac death. Magnetocardiographs (MCG) can detect early heart muscle ischemia. However, the clinical parameters for using MCGs to identify heart ischemia are poorly understood. Therefore, we examined the details of the magnetic field variation and related physiological parameters for a re-entry wave in 3D cardiac tissue. We used a new human cardiac cell model to simulate action potential (AP) propagation in a 3D rectangular parallelepiped block of tissue, and a finite element method and Galerkin approximation to discretize the 3D domain spatially. The re-entry wave was …

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