AIMEDIC Publications

Modelling Cl− homeostasis and volume regulation of the cardiac cell

Category

Pub

Date

2006-05-15

Source

Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences

We aim at introducing a Cl− homeostasis to the cardiac ventricular cell model (Kyoto model), which includes the sarcomere shortening and the mitochondria oxidative phosphorylation. First, we examined mechanisms underlying the cell volume regulation in a simple model consisting of Na+/K+ pump, Na+–K+–2Cl− cotransporter 1 (NKCC1), cystic fibrosis transmembrane conductance regulator, volume-regulated Cl− channel and background Na+, K+ and Cl− currents. The high intracellular Cl− concentration of approximately 30 mM was achieved by the balance between the secondary active transport via NKCC1 and passive currents. Simulating responses to Na+/K+ pump inhibition revealed the essential role of Na+/K+ pump in maintaining the cellular osmolarity through creating the negative membrane potential, which extrudes Cl− from a cell, confirming the previous model study in the skeletal muscle. In …

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