AIMEDIC Publications

Computational modeling of cardiovascular response to orthostatic stress

Category

Pub

Date

2002-03-01

Source

Journal of applied physiology

The objective of this study is to develop a model of the cardiovascular system capable of simulating the short-term (≤5 min) transient and steady-state hemodynamic responses to head-up tilt and lower body negative pressure. The model consists of a closed-loop lumped-parameter representation of the circulation connected to set-point models of the arterial and cardiopulmonary baroreflexes. Model parameters are largely based on literature values. Model verification was performed by comparing the simulation output under baseline conditions and at different levels of orthostatic stress to sets of population-averaged hemodynamic data reported in the literature. On the basis of experimental evidence, we adjusted some model parameters to simulate experimental data. Orthostatic stress simulations are not statistically different from experimental data (two-sided test of significance with Bonferroni adjustment for …

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